When an item frame is filled with an item, the sound it makes when it is filled repeats every tick. The sound stops repeating when the item is removed.
Steps to reproduce:
1. Place down an item frame.
2. Place an item into it.
The sound "Item Frame Fills" will play every tick.
3. Remove the item.
The sound will stop.
Sorry that I had to link the video here. It doesn't show up correctly as an attachment for me.
Environment
Windows 10 Home 64-bit
Java version 1.8.0_111-b14
Java SE Runtime Environment build 1.8.0_111-b14
Are you using any entitydata commands that can target item frames?