Opened Minecraft Launcher, played latest snapshot 18w09a, tried to click singleplayer, it took several clicks for it to finally open the world menu, then created a new world, everything took as many as 15 clicks to activate, once the world loaded my mouse continued to show on the screen and I could not interact with any blocks in the world, all I could do was move and fly and deal with the slow chunk loading.
Cannot reproduce at all in 1.13-pre5