I have always (since v1.5.2) noticed that my machine runs slower when a slime is making noise. This slowdown also happens around lava flows and water... It 'feels' like the sound is being serialized in the pipeline - causing it to back up other processes and if the sound file is a bit long, this exacerbates the issue...
Please force a crash by pressing F3 + C for 10 seconds while ingame and attach the crash report here.