If you throw a level 124 damage potion into a sulfur cube with a block, the TPS will become zero.
Steps to reproduce the issue:
Summon a sulfur cube.
Place any block in it.
Write command:
/give @s splash_potion[potion_contents={custom_effects:[{id:instant_damage,duration:1,amplifier:124}]}]Throw a potion into a sulfur cube.
Expected result: the sulfur cube will die.
Actual result: TPS becomes zero.
Can confirm.