I cannot force 2x2 spruce trees to grow with bonemeal in certain locations, neither can I let it grow naturally.
EDIT: It seems like it works like this in certain biomes and won't in other biomes. Will update when I got a more complete list.
EDIT again: A few biomes it certainly affects:
-Snowy Mountains
-Snowy Tundra
-Snowy Taiga
-Plains
-Sunflower Plains
-Mountains
Steps to reproduce:
Place 2x2 spruce saplings
Bonemeal it
Notice it: a) won't grow, or b) will grow
In case of b, try again on another location.
Here is a video showcasing it, in case it wasn't clear yet: https://youtu.be/Wm7MCeb0cHE
Related issues
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Can confirm this bug is still present in pre-release 9 within Mushroom Island biomes.