Cannot select certain sections of my inventory

Hello, I'm having an issue with the top right section of my inventory, also if i open chests it becomes the bottom right corner of the chest inventory that begins to have problems. I have to click it numerous amounts of times and sometimes it still won't register that I've clicked on anything. My mouse pointer also glitches and freezes up around the top right corner in my inventory and makes it impossible to try and do stuff easily with a full inventory. please help!