Sometimes when I load up my game I can't access certain parts of my inventory, my mouse cursor will go over the area but I can't select the items in the inventory. This carries over as when I press esc to open the UI menu I can't click in the same spots.
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No, it is only a 1.14 problem, it use to be just when I opened my inventory with E but only now started when I tried to use an enchantment table, crafting book, or open a chest. I tried using my trackpad and a different mouse but nothing worked.
I haven't experienced this problem so it must be because to your computer not being good enough to run Minecraft.
Again, this is just sometimes, it's the only issue I have with the current update, I can even run 1.14.4 normally on my spare school laptop. I was able to fix it last night by switching touchscreen mode on/off but that didn't seem to work this morning. I can run the snapshots and 1.13 just fine, I was mainly hoping someone had a fix to this until 1.15 comes around. I will try restarting some drivers again but I have never seen this issue with any other game.
I'm not really sure, I've never had this happen to me before, if you could give a little bit more detail on when the bug occurs for example, after a long time when playing, when you just start the game, etc.
Does MC-143776 describe your issue?
It sounds like your mouse is broken, or your computer just can't run Minecraft that well.