Though a 1 redstone-tick pulse don't activate comparators from its main input, it will deactivate it when comparing or subtracting redstone signals, as long as a comparator is facing into the side of a repeater locking it. Otherwise, the comparator will not be deactivated. Either this shouldn't happen since comparators aren't normally affected by 1 redstone-tick pulses, or comparators not being affected normally by 1 redstone-tick pulses is a bug.
How to reproduce:
Place a comparator.
Put a container behind the comparator with one item in it.
Have redstone dust next to the comparator.
Have an observer block facing into the redstone dust.
Put a repeater sideways in front of the comparator, locking it.
When you activate the observer, the repeater will unlock, then relock.
Related MC-109737