Recently I have had the problem that the bees esters in Minecraft are empty and there are no more bienne on the map. The bees didn't sting or anything or there was water nearby. After the last update they were gone.
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@unknown: thanks for your reply. Since the bees were enclosed, this is the same issue as MCPE-21416. I will have this report resolved as a duplicate.
The issue with beehives being backwards in 1.16.20 is tracked at MCPE-92468. However, the hive direction has no impact on entering and exiting (at least in Bedrock Edition; it may be a Java-exclusive behavior).
Most likely, they randomly despawned (MCPE-21416), or they wandered away (MCPE-41092). If they didn’t have flowers nearby they may have gone looking for them. Search a little farther and you should find new bees and nests.