_is2u

Can confirm in 1.17.1 with the differential that it can delete an item and item stack.

           Reproduction metod:

               After performing the bug, opening and closing your inventory deletes the item, it will                 also works with an stack if dropped control is pressed.

^{edit:  After closing the inventory, i am constantly inputing Q and Right Mouse Button to see if it happens to have any interactions.}